Synthesis and antimalarial evaluation of new N1-(7-chloro-4-quinolyl)-1,4-bis(3-aminopropyl)piperazine derivatives |
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Authors: | Ryckebusch Adina Debreu-Fontaine Marie-Ange Mouray Elisabeth Grellier Philippe Sergheraert Christian Melnyk Patricia |
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Institution: | Institut de Biologie et Institut Pasteur de Lille-UMR CNRS 8525-Université de Lille II 1 rue du Professeur Calmette, B.P. 447, 59021 Lille, France. |
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Abstract: | Synthesis and evaluation of the activity of new N(1)-(7-chloro-4-quinolyl)-1,4-bis(3-aminopropyl)piperazine derivatives against a chloroquine-resistant strain of Plasmodium falciparum are described. Selectivity indices were improved for two compounds versus the lead 1, the bis-cyclopropylmethyl derivative, thus increasing the therapeutic interest of our family. As our previous studies conducted on the mode of action of our compounds made us hypothesize the existence of original mechanisms and/or original targets, terminal amino derivatives can be considered as promising tools further mechanistical studies, as probes for affinity chromatography. |
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