Synthesis and antimicrobial activity of novel globomycin analogues |
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| Authors: | Kiho Toshihiro Nakayama Mizuka Yasuda Kayo Miyakoshi Shunichi Inukai Masatoshi Kogen Hiroshi |
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| Affiliation: | Exploratory Chemistry Research Laboratories, Sankyo Co., Ltd., 140-8710, Tokyo, Japan. |
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| Abstract: | Globomycin, a signal peptidase II inhibitor, and its derivatives show potent antibacterial activity against Gram-negative bacteria. The synthesis and antimicrobial activity of novel globomycin analogues are reported. One of the analogues showed a more potent activity against Gram-negative bacteria than globomycin and also exhibited antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA). |
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