Melanin-concentrating hormone,hippocampal nitric oxide levels and memory retention |
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Authors: | Varas Mariana Pérez Mariela Monzón María Elena de Barioglio Susana Rubiales |
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Affiliation: | Departamento de Farmacología, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, 5000, Córdoba, Argentina |
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Abstract: | The present study attempts to determine, if the effect of melanin-concentrating hormone (MCH) upon memory retention is correlated with changes in nitric oxide synthase (NOS) activity and tissue levels of nitric oxide (NO) and cGMP. We used a behavioral experiment using a step-down inhibitory avoidance test, the biochemical determinations of NO and cGMP, and electrophysiological model. Results of behavioral studies (step-down test) showed that MCH administration reverts the amnesic effects induced by N(G)-nitro-L-arginine (L-NOArg). Moreover, electrophysiological studies demonstrated that L-NOArg did not block the potentiation induced by the peptide. Hippocampal NO and cGMP levels increased after MCH injection. |
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Keywords: | MCH Hippocampus Nitric oxide cGMP Synaptic transmission Behavior |
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