Adrenocortical response to corticotropin is inhibited by gamma 3-MSH antisera in normotensive and spontaneously hypertensive rats |
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| Authors: | B Sharp J R Sowers |
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| Affiliation: | 1. Department of Medicine, Hennepin County Medical Center-University of Minnesota, Minneapolis, MN, USA;2. Department of Medicine McGuire Veteran''s Administration Center-Virginia Commonwealth University, Richmond, VA, USA |
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| Abstract: | In order to further investigate the coordinate action of pro-corticotropin/endorphin-derived peptides on adrenal steroidogenesis, we have evaluated the effects of highly specific antisera to synthetic rat gamma 3-MSH (1-27) peptide (gamma 3-MSH Ab) on corticosterone, 18-hydroxycorticosterone and aldosterone responses to ACTH (1-24) in chronically cannulated spontaneously hypertensive rats (SHR) and their normotensive controls (WKY). Antisera eliminated the ACTH induced rise of all three corticosteroids. It had no effect on basal corticosteroid levels. Our results offer further evidence that the potentiating action of gamma 3-MSH may play an important role in modulating ACTH induced steroidogenesis. |
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