Natriuretic and diuretic effects of endothelin in isolated perfused rat kidney |
| |
| Authors: | K Nitta M Naruse T Sanaka K Tsuchiya K Naruse Z P Zeng H Demura N Sugino |
| |
| Institution: | Department of Medicine, Tokyo Women's Medical college, Japan. |
| |
| Abstract: | In an attempt to clarify the pathophysiological role of endothelin (ET), a novel vasoconstrictor peptide, we administered this peptide into the medium of isolated perfused rat kidney (IPK). ET increased renal vascular resistance by 53%, and reduced inulin clearance by 29% in IPK at a higher concentration of 500 PM. However, fractional excretion of sodium and urine flow rate were increased by 160% and 109%, respectively. These findings suggest that ET modulates the tubular sodium reabsorption as well as the renal hemodynamics. |
| |
| Keywords: | |
|
|
