Anti-autophagic Bcl-2: Not just an innocent bystander |
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Authors: | Oh Soohwan Pirooz Sara Dolatshahi Ni Duojiao Zhao Zhen Liang Chengyu |
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Affiliation: | Department of Molecular Microbiology and Immunology, University of Southern California, Los Angeles, CA, USA. |
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Abstract: | Bcl-2, originally identified as a universal inhibitor of apoptotic cell death, has since been implicated in suppressing autophagy, the cell's quality control mechanism. Our recent study demonstrates that the anti-autophagic aspect of Bcl-2 can function as a promoter of oncogenic growth, independently of its role in apoptosis signaling. It is likely that the increase in Bcl-2 often seen in breast and other cancers might render cells error-prone by blunting autophagy, while concomitantly keeping damaged cells alive. The outcome of such a 'double hit' of Bcl-2 may synergistically promote tumor growth and increase the chance of cancer development and drug resistance. |
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Keywords: | Bcl-2 autophagy apoptosis breast cancer tumorigenesis |
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