Effect of Antioxidant Diets on Mitochondrial Gene Expression in Rat Brain During Aging |
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Authors: | V G Nicoletti V M Marino C Cuppari D Licciardello D Patti V Spina Purrello A M Giuffrida Stella |
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Institution: | (1) Department of Chemical Sciences, Section of Biochemistry & Molecular Biology, University of Catania, Viale A. Doria 6, Catania, 95125, Italy |
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Abstract: | Age-related increase of reactive oxygen species (ROS) is particularly detrimental in postmitotic tissues. Calorie restriction
(CR) has been shown to exert beneficial effects, consistent with reduced ROS generation by mitochondria. Many antioxidant
compounds also mimic such effects. N-acetyl cysteine (NAC) provides thiol groups to glutathione and to mitochondrial respiratory chain proteins; thus, it may
counteract both ROS generation and effects. In the present study we investigated, in different rat brain areas during aging
(6, 12, and 28 months), the effect of 1-year treatment with CR and dietary supplementation with NAC on the expression of subunit
39 kDa and ND-1 (mitochondrial respiratory complex I), subunit IV (complex IV), subunit α of F0F1-ATP synthase (complex V) and of adenine nucleotide translocator, isoform 1 (ANT-1). The observed age-related changes of expression
were prevented by the dietary treatments. The present study provides further evidence for the critical role of mitochondria
in the aging process. |
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Keywords: | Aging diet gene expression mitochondria N-acetyl cysteine oxidative stress |
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