Androgen metabolism by rat epididymis. 1. Metabolic conversion of 3 H-testosterone in vivo |
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Authors: | O Djoseland V Hansson H N Haugen |
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Affiliation: | Laboratory of Endocrinology, Medical Department B and Laboratory of Histochemistry, Institute of Pathology, Rikshospitalet, Oslo, Norway |
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Abstract: | The epididymis of adult rats metabolize 3H-testosterone by experiments . Thirty minutes after the injection of 100 μCi 3H-testosterone, some 10 per cent of the total radioactivity of the epididymis was found in the water-soluble fraction, whereas 90 per cent was found in the ether soluble fraction (free steroids). The free steroids were examined further and the following androgenic metabolites identified: (17β-hydroxy-4-androsten-3-one) 8, 9%, (4-androstene-3, 17-dione, 2,7%, (5α-androstane-3, 17-dione) 6,5%, (17β-hydroxy-5α-androstan-3-one) 47, 2%, (5α-androstane-3β, 17β-diol) 4, 4%, (5α-androstane-3α,17β-diol) 20, 8% and (3α-hydroxy-5α-androstan-3-one) 3,4%. The relative amount of each metabolite is given in per cent of total radioactivity in the ether soluble fraction. |
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