Some aspects of oligoribonucleotides synthesis via the H-phosphonate approach. |
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Authors: | J Stawiński A Kraszewski |
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Institution: | Stockholm University, Department of Organic Chemistry, Sweden. js@lab12.organ.su.se |
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Abstract: | This review gives a short account of selected aspects of oligoribonucleotide synthesis via the H-phosphonate method. It includes: (i) recent methods for the preparation of suitably protected ribonucleoside 3'-H-phosphonates (the phosphonylation step), (ii) some chemical and stereochemical features of the formation of H-phosphonate internucleosidic linkages, and (iii) stereoselective synthesis of oligoribonucleoside phosphorothioates using chemo-enzymatic approach. |
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