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Carnosic acid, a catechol-type electrophilic compound, protects neurons both in vitro and in vivo through activation of the Keap1/Nrf2 pathway via S-alkylation of targeted cysteines on Keap1 |
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| Authors: | Satoh Takumi Kosaka Kunio Itoh Ken Kobayashi Akira Yamamoto Masayuki Shimojo Yosuke Kitajima Chieko Cui Jiankun Kamins Joshua Okamoto Shu-ichi Izumi Masanori Shirasawa Takuji Lipton Stuart A |
| Affiliation: | Department of Welfare Engineering, Faculty of Engineering, Iwate University, Morioka, Iwate, Japan; Research and Development Center, Nagase Co., Ltd. Kobe, Hyogo, Japan; Department of Stress Science, Hirosaki University School of Medicine, Hirosaki, Aomori, Japan; Department of Medical Chemistry, Medical School, Tohoku University, Sendai, Miyagi, Japan; Center for Neuroscience, Aging and Stem Cell Research, The Burnham Institute for Medical Research, La Jolla, California, USA; Research Team for Molecular Biomarkers, Tokyo Metropolitan Institute of Gerontology, Itabashi-ku, Tokyo, Japan |
| Abstract: | |
| Keywords: | carnosic acid cysteine thiol Keap1 neurite outgrowth-promoting prostaglandin 11 Nrf2 S-alkylation |
| 本文献已被 PubMed 等数据库收录！ | |