The path toward identifying prostatic stem cells |
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Authors: | Taylor Renea A Risbridger Gail P |
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Institution: | Centre for Urological Research, Monash Institute of Medical Research, Monash University, Australia Fax: +61 3 9594 7420 |
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Abstract: | Abstract The concept that stem cells reside in prostate epithelia is well accepted and has led to significant efforts aimed at isolating and characterizing adult prostate stem/progenitor cells from both human and rodent prostate tissues. Understanding how prostatic stem and/or progenitor cells give rise to prostate epithelia during development and maintain homeostasis of the prostate gland in adulthood is a major research focus. Furthermore, the ability to identify and manipulate prostatic stem cells (PSCs) holds enormous promise for the development of new approaches to manage and treat prostate cancer. This review maps the pathways to identifying, isolating, characterizing, and understanding the differentiation capacity of PSCs. |
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Keywords: | stem cell niche differentiation CD133 |
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