A heritable fragile 12q24.13 segregating in a family with the fragile X chromosome |
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| Authors: | Anthony P. Amarose Peter R. Huttenlocher Rita M. Sprudzs Thomas J. Laitsch Mark J. Pettenati |
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| Affiliation: | (1) Department of Obstetrics and Gynecology, The Pritzker School of Medicine, The University of Chicago, 5841 South Maryland Avenue, 60637 Chicago, IL, USA;(2) Department of Pediatrics and Neurology, The Pritzker School of Medicine, The University of Chicago, 5841 South Maryland Avenue, 60637 Chicago, IL, USA;(3) Department of Medicine, The Pritzker School of Medicine, The University of Chicago, 5841 South Maryland Avenue, 60637 Chicago, IL, USA;(4) Present address: Department of Pediatrics, Bowman Gray School of Medicine of Wake Forest University, 27103 Winston-Salem, NC, USA |
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| Abstract: | Summary A fragile site on chromosome 12, at 12q24.13, was found in the lymphocytes of two members of a family during the study for detection of a fragile X chromosome. The site was found to be heritable and folate-sensitive, and it fulfills all four criteria for a fragile site. It thus can now be confirmed as the heritable fragile site FRA12C. |
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