Gait changes precede overt arthritis and strongly correlate with symptoms and histopathological events in pristane-induced arthritis |
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| Authors: | Markus H Hoffmann Rudolf Hopf Birgit Niederreiter Heinz Redl Josef S Smolen Günter Steiner |
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| Affiliation: | (1) Division of Rheumatology, Internal Medicine III, Medical University of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria;(2) Ludwig Boltzmann Institute for Experimental and Clinical Traumatology in the AUVA Research center for Traumatology and Austrian Cluster for Tissue Regeneration, Donaueschingenstrasse 13, A-1200 Vienna, Austria |
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| Abstract: | Introduction Pristane-induced arthritis (PIA) in the rat has been described as an animal model of inflammatory arthritis which exhibits features similar to rheumatoid arthritis in humans, such as a chronic, destructive, and symmetrical involvement of peripheral joints. However, so far little is known about the earliest inflammatory events and their influence on locomotor behaviour during the course of PIA. To investigate this issue a detailed analysis of the pathologic changes occurring during the prodromal and early stages of PIA was performed. |
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