Neutralizing the free radicals could alleviate the disease severity following an infection by positive strand RNA viruses |
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| Authors: | Agieshkumar Balakrishna Pillai Aashika Raagavi JeanPierre Vignesh Mariappan Pajanivel Ranganadin Rao S.R. |
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| Affiliation: | 1.Central Inter-Disciplinary Research Facility (CIDRF), School of Biological Sciences, MGM Advanced Research Institute (MGMARI), Sri Balaji Vidyapeeth (Deemed To Be University), Puducherry, 607 402 India ;2.Mahatma Gandhi Medical College and Research Institute (MGMCRI), Sri Balaji Vidyapeeth (Deemed To Be University), Puducherry, 607 402 India ;3.Research, Innovation & Development, Sri Balaji Vidyapeeth (Deemed To Be University), Puducherry, 607 402 India |
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| Abstract: | Free radical release due to oxidative stress is gaining importance in the field of viral pathogenesis. Recent studies suggest the involvement of oxidative stress and ROS levels in regulating disease virulence during RNA virus infection. Most of the RNA virus infections lead to vascular dysfunction and disease severity. However, the biology of free radicals in maintaining vascular endothelium integrity is not completely understood. In the present review, we discuss some of the common features in positive-strand RNA virus infections such as dengue and SARS-CoV-2 and suggest that anti-oxidant therapy could pave the way to develop therapeutic strategies in combating emerging and re-emerging RNA viruses.Supplementary InformationThe online version contains supplementary material available at 10.1007/s12192-022-01269-x. |
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| Keywords: | RNA virus ROS Anti-oxidant therapy COVID-19 Endothelial activation |
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