肠道菌群变化对初产妇妊娠期糖尿病和妊娠结局及远期心血管事件的影响

目的 分析妊娠早期肠道菌群变化对初产妇妊娠期糖尿病、妊娠结局及远期心血管事件的影响。 方法 选择2010年3月至2014年12月我院收治的2 634例初产妇,按照是否为妊娠期糖尿病分为正常妊娠组(NC组)和妊娠期糖尿病组(GDM组),分析两组对象肠道菌群的变化。观察不同妊娠结局GDM患者肠道菌群变化情况以及随访心血管事件发生情况。 结果 GDM组对象BMI、FPG、HbA1c、TG、HDL C、HOMA IR、Fins、BUN、hs CRP、PLGF和肠道总细菌、拟杆菌属、双歧杆菌属、乳杆菌属、肠球菌属数量与NC组比较差异均有统计学意义(均P结论 妊娠早期肠道益生菌下降与GDM的发生具有显著相关性,GDM患者肠道部分益生菌及肠球菌与GDM患者不良妊娠结局和心血管事件存在一定关系,值得进一步研究。

The relationship between intestinal flora and gestational diabetes, pregnancy outcomes and long term cardiovascular events in primiparas

Objective To explore the relationship between the changes of intestinal microbiota in early pregnancy and gestational diabetes, pregnancy outcome and long term cardiovascular events in primiparas. Methods A total of 2,634 primiparas treated in our hospital from Mar 2010 to Dec 2014 were divided into normal pregnancy group (NC group) or gestational diabetes group (GDM group) according to whether they had gestational diabetes. The changes of intestinal flora and the occurrence of cardiovascular events during follow up of GDM patients with different pregnancy outcomes were observed. Results In GDM group, the BMI, FPG, HbA1c, TG, HDL C, HOMA IR, Fins, BUN, hs CRP, PLGF, total intestinal bacteria, Bacteroides, Bifidobacterium, Lactobacillus and Enterococcus were statistically significantly different compared with NC group (all PConclusion The decline of intestinal probiotics in early pregnancy is significantly related to the occurrence of GDM. Some intestinal probiotics and Enterococci have a certain relationship with adverse pregnancy outcomes and cardiovascular events in GDM patients.