DNA breaks generated by the bleomycin-iron III complex in the presence of KHSO5, a single oxygen donor |
| |
| Authors: | G Pratviel J Bernadou B Meunier |
| |
| Affiliation: | 1. School of River and Ocean Engineering, Chongqing Jiaotong University, Chongqing 400074, China;2. Key Laboratory of Three Gorges Reservoir Region''s Eco-Environment, Ministry of Education, Chongqing University, Chongqing 400045, China;3. National Centre for International Research of Low-carbon and Green Buildings, Chongqing University, Chongqing 400045, China;4. T.Y. Lin International Engineering Consulting (China) Co., Ltd, Chongqing 401121, China |
| |
| Abstract: | KHSO5, a water soluble single oxygen donor, is shown to be capable of activating bleomycin-FeIII complex for DNA cleavage. DNA breaks mediated by bleomycin-FeIII in the presence of H2O2 or KHSO5 are compared and the P450-like activation of metallobleomycins is discussed. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
