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DNA breaks generated by the bleomycin-iron III complex in the presence of KHSO5, a single oxygen donor |
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| Authors: | G Pratviel J Bernadou B Meunier |
| Abstract: | KHSO5, a water soluble single oxygen donor, is shown to be capable of activating bleomycin-FeIII complex for DNA cleavage. DNA breaks mediated by bleomycin-FeIII in the presence of H2O2 or KHSO5 are compared and the P450-like activation of metallobleomycins is discussed. |
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