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A comparative analysis of DNA methylation across human embryonic stem cell lines
Authors:Pao-Yang Chen  Suhua Feng  Jong Wha Joanne Joo  Steve E Jacobsen  Matteo Pellegrini
Affiliation:(1) Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, CA 90095, USA;(2) Institute of Genomics and Proteomics, University of California, Los Angeles, CA 90095, USA;(3) Interdepartmental Program in Bioinformatics, University of California Los Angeles, Los Angeles, CA 90095, USA;(4) Howard Hughes Medical Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA;(5) Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, Los Angeles, CA 90095, USA;(6) Molecular Biology Institute, University of California, Los Angeles, CA 90095, USA
Abstract:

Background  

We performed a comparative analysis of the genome-wide DNA methylation profiles from three human embryonic stem cell (HESC) lines. It had previously been shown that HESC lines had significantly higher non-CG methylation than differentiated cells, and we therefore asked whether these sites were conserved across cell lines.
Keywords:
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