Application of a two-stage temperature control strategy for enhanced glutathione production in the batch fermentation by Candida utilis |
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| Authors: | Wei Gongyuan Li Yin Du Guocheng Chen Jian |
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| Institution: | (1) Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Southern Yangtze University, Wuxi, 214036, P.R. China;(2) Key Laboratory of Industrial Biotechnology, Ministry of Education and Laboratory of Environmental Biotechnology, School of Biotechnology, Southern Yangtze University, Wuxi, 214036, P.R. China |
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| Abstract: | In batch culture for glutathione production with Candida utilis, a higher temperature (30 °C) was required to hasten cell growth while a lower temperature (26 °C) was needed to increase the production of glutathione. A two-stage temperature control strategy was used to enhance both the yield and the productivity of glutathione. As a result, glutathione production was increased by 5% and 23% of that at 26 °C and 30 °C, respectively, and the intracellular glutathione content reached 2.5% (w/w). |
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| Keywords: | batch fermentation Candida utilis glutathione temperature two-stage strategy |
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