Syntheses of quinolone hydrochloride enantiomers from synthons (R)- and (S)-2-methylpiperazine |
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| Authors: | Liu Bo Yang Chun-Hao Xu Guang-Yu Zhu Yong-Hong Cui Jing-Rong Wu Xi-Han Xie Yu-Yuan |
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| Institution: | State Key Laboratory of Drug Research, Shanghai Institute of Meteria Medica, SIBS, Chinese Academy of Sciences, Graduate School of the CAS, 555 Zuchongzhi Road, Shanghai 201203, PR China. |
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| Abstract: | A series of R and S enantiomers of 7-(3-methylpiperazin-1-yl) quinolone derivatives were synthesized from (R)- and (S)-tert-butyl 2-methylpiperazine-1-carboxylate and tested for their antibacterial activities on 14 kinds of bacteria. Although no distinct difference in in vitro antibacterial activities was observed, 2-64-fold difference between R and S enantiomers was observed in approximately 52% of cases. |
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