Fibrinolytic and hypoglycemic effects of the Pro-Gly-Pro-Leu peptide during development of insulin-dependent diabetes in rats |
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Authors: | L. A. Lyapina N. F. Myasoedov L. A. Andreeva A. M. Ul’yanov T. Yu. Obergan T. A. Shubina V. E. Pastorova |
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Affiliation: | 1.Department of Physiology of Humans and Animals, Faculty of Biology,Moscow State University,Moscow,Russia;2.Institute of Molecular Genetics,Russian Academy of Sciences,Moscow,Russia |
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Abstract: | Repeated (over 7 days) intranasal introduction of the Pro-Gly-Pro-Leu peptide into animals at a dose of 1 mg/kg before injection of the diabetogenic metabolite alloxan provided effective protection of an organism against development of insulin-dependent diabetes mellitus and prevented development of hyper-coagulating alterations in the system of hemostasis. An increasing in the anticoagulating and fibrinolytic activities in rat blood plasma was detected. The peptide under study also showed antidiabetogenic action: repeated intranasal introduction of the Pro-Gly-Pro-Leu peptide into animals for 7 days inhibited development of diabetes symptoms in rats pretreated with alloxan. |
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