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Beyond traditional therapy: Mucoadhesive polymers as a new frontier in oral cancer management
Authors:Subhayan Das  Koushik Bhattacharya  Jonny J. Blaker  Nikhil K. Singha  Mahitosh Mandal
Affiliation:1. School of Medical Science and Technology, Indian Institute of Technology Kharagpur, Kharagpur, India;2. Rubber Technology Centre, Indian Institute of Technology Kharagpur, Kharagpur, India;3. Bio-Active Materials Group, Department of Materials and Henry Royce Institute, The University of Manchester, Manchester, UK

Department of Biomaterials, Institute of Clinical Dentistry, University of Oslo, Oslo, Norway

Abstract:In recent times mucoadhesive drug delivery systems are gaining popularity in oral cancer. It is a malignancy with high global prevalence. Despite significant advances in cancer therapeutics, improving the prognosis of late-stage oral cancer remains challenging. Targeted therapy using mucoadhesive polymers can improve oral cancer patients' overall outcome by offering enhanced oral mucosa bioavailability, better drug distribution and tissue targeting, and minimizing systemic side effects. Mucoadhesive polymers can also be delivered via different formulations such as tablets, films, patches, gels, and nanoparticles. These polymers can deliver an array of medicines, making them an adaptable drug delivery approach. Drug delivery techniques based on these mucoadhesive polymers are gaining traction and have immense potential as a prospective treatment for late-stage oral cancer. This review examines leading research in mucoadhesive polymers and discusses their potential applications in treating oral cancer.
Keywords:biomaterials  drug delivery  mucoadhesive polymers  oral cancer
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