Evaluation of cytotoxic,antifungal, and larvicidal activities of different bis-sulfonamide Schiff base compounds |
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Authors: | Hasan Aydin Süleyman Akocak Nebih Lolak Önder Yumrutaş Uğur Uslu Ibrahim Bozgeyik Fatih Üçkardeş Selami Günal Onur Ceylan |
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Affiliation: | 1. Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Adıyaman University, Adıyaman, Türkiye;2. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Adıyaman University, Adıyaman, Türkiye;3. Department of Medical Biology, Faculty of Medicine, Adıyaman University, Adıyaman, Türkiye;4. Department of Medical Microbiology, Faculty of Medicine, Selçuk University, Konya, Türkiye;5. Department of Biostatistics, Adıyaman University, Adıyaman, Türkiye;6. Department of Pharmaceutical Microbiology, Faculty of Pharmacy, İnönü University, Malatya, Türkiye;7. Department of Parasitology, Faculty of Veterinary Medicine, Selçuk University, Konya, Türkiye |
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Abstract: | Schiff bases (imines or azomethines) are versatile ligands synthesized from the condensation of amino compounds with active carbonyl groups and used for many pharmaceutical and medicinal applications. In our study, we aimed to determine the cytotoxic, antifungal and larvicidal activities of biologically potent bis-sulfonamide Schiff base derivatives that were re-synthesized by us. For this aim, 16 compounds were re-synthesized and tested for their cytotoxic, antifungal and larvicidal properties. Among this series, compounds A1B2 , A1B4 , A4B2 , A4B3 , and A4B4 were shown to have cytotoxic activity against tested cancer lung cell line (A549). The most potent antifungal activity was observed in compounds A2B1 and A2B2 against all fungi. A1B1 showed the strongest larvicidal effect at all concentrations at the 72nd h (100% mortality). These obtained results demonstrate that these type of bis-substituted compounds might be used as biologically potent pharmacophores against different types of diseases. |
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Keywords: | antifungal activity cytotoxicity larvicidal activity Schiff base |
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