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Siparuna guianensis Essential Oil Antitumoral Activity on Ehrlich Model and Its Effect on Oxidative Stress |
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| Authors: | Lucas Gabriel Viana Barbosa Ellen Nayara Silva de Jesus Lucas Botelho Jerônimo Jamile Silva da Costa Renata Cunha Silva Prof Dr William N Setzer Prof Dra Joyce Kelly R da Silva Prof Dr Jofre Jacob da Silva Freitas Prof Dr Pablo Luis B Figueiredo |
| Institution: | 1. Laboratório de Química dos Produtos Naturais, Universidade do Estado do Pará, Belém, 66087-662 Brazil
Laboratório de Morfofisiologia Aplicada a Saúde, Departamento de Morfologia e Ciências Fisiológicas, Universidade do Estado do Pará, Belém, 66087-662 Brazil.;2. Laboratório de Química dos Produtos Naturais, Universidade do Estado do Pará, Belém, 66087-662 Brazil;3. Laboratório de Morfofisiologia Aplicada a Saúde, Departamento de Morfologia e Ciências Fisiológicas, Universidade do Estado do Pará, Belém, 66087-662 Brazil.;4. Aromatic Plant Research Center, 230 N 1200 E, Suite 100, Lehi, UT, 84043 USA;5. Aromatic Plant Research Center, 230 N 1200 E, Suite 100, Lehi, UT, 84043 USA Programa de Pós-Graduação em Biotecnologia, Universidade Federal do Pará, Belém, 66075-900 Brazil |
| Abstract: | This work aims to evaluate the chemical composition, in vitro antioxidant capacity, and in vivo antitumoral activity of S. guianensis essential oil against Ehrlich's ascitic carcinoma and the effects on oxidative stress. The animals (Mus musculus) received a daily dose of S. guianensis oil orally (100 mg/kg) for 9 days. The main constituents of essential oil were curzerenone (16.4±1.5 %), drimenol (13.7±0.2 %), and spathulenol (12.4±0.8 %). S. guianensis oil showed antioxidant activity, inhibiting 11.1 % of DPPH radicals (95.7 mgTE/g); and 15.5 % of the β-carotene peroxidation. The group treated with S. guianensis showed a significant reduction in tumor cells (59.76±12.33) compared to the tumor group (96.88±19.15). Essential oil of S. guianensis decreased MDA levels and increased SOD levels in liver tissue. The essential oil of S. guianensis reduced oxidative stress, and showed antitumor and antioxidant activity, being characterized as a new chemical profile in the investigation of pathologies such as cancer. |
| Keywords: | anticancer ascitic carcinoma in vivo model MDA and SOD sesquiterpenes |