NO-independent stimulators of soluble guanylate cyclase |
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| Authors: | Straub A Stasch J P Alonso-Alija C Benet-Buchholz J Ducke B Feurer A Fürstner C |
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| Affiliation: | Institute of Medicinal Chemistry, Pharma Research Centre, Bayer AG, Wuppertal, FRG. alexander.straub.as@bayer-ag.de |
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| Abstract: | SARs around a novel type of guanylate cyclase stimulator which act by a mechanism different from classical NO-donors are described. Several pyrazolopyridinylpyrimidines are shown to relax aortic rings and revealed a long-lasting blood pressure lowering effect in rats after oral application. |
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