VISSA: a program to visualize structural features from structure sequence alignment |
| |
Authors: | Li Weizhong Godzik Adam |
| |
Institution: | Burnham Institute for Medical Research, La Jolla, CA 92037, USA. liwz@burnham.org |
| |
Abstract: | MOTIVATION: Multiple sequence alignment is an important tool to understand and analyze functions of homologous proteins. However, the logic of residue conservation/variation is usually apparent only in three-dimensional (3D) space, not on a primary sequence level. Thus, in a traditional multiple alignment it is often difficult to directly visualize and analyze key residues because they are masked by other residues along the alignment. Here we present an integrated multiple alignment and 3D structure visualization program that can (1) map and highlight residues from a 1D alignment onto a 3D structure and vice versa and (2) display only the alignment of preselected, key residues. This program, called Visualize Structure Sequence Alignment, also has many other built-in tools that can help analyze multiple sequence alignments. AVAILABILITY: http://bioinformatics.burnham.org/liwz/vissa CONTACT: liwz@burnham.org. |
| |
Keywords: | |
本文献已被 PubMed Oxford 等数据库收录! |
|