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Polymorphisms of MLH1 in benign prostatic hyperplasia and sporadic prostate cancer |
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| Authors: | Yuichiro Tanaka Mohd S. Zaman Jan Liu Hiroaki Shiina Angela V. Dahiya Koichi Nakajima |
| Affiliation: | a Department of Surgery/Urology (112F), Veterans Affairs Medical Center, University of California, 4150 Clement St., San Francisco, CA 94121, USA b Department of Urology, Shimane University School of Medicine/Nursing, 89-1 Enya-cho, Izumo City, Shimane 693-8501, Japan c Department of Urology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka Suita, Osaka 565-0871, Japan d Department of Epidemiology and Biostatistics, University of California, 185 Berry Street, San Francisco, CA 94143, USA e Department of Urology, Toho University Faculty of Medicine, 5-21-16 Omorinishi, Ota-ku, Tokyo 143-8540, Japan |
| Abstract: | Mismatch repair is one of several DNA repair pathways of which defects may lead to cancer. We hypothesize that polymorphisms of the MLH1 gene can be a risk factor for benign prostatic hyperplasia (BPH) and prostate cancer. The genetic distribution of MLH1 polymorphisms that lead to amino acid changes at codons 132, 219, 384, and 723 were analyzed in BPH and sporadic prostate cancer patients, and compared to healthy controls from an Asian population. These experiments demonstrate a protective role for the codon 384 variant allele against prostate cancer (P = 0.031) but not BPH when compared to normal controls and furthermore, an inverse association was observed with stage (P = 0.074) and grade (P = 0.056) of cancer. This is the first report that demonstrates a protective effect for the race-related MLH1 polymorphism at codon 384 against prostate cancer and these results are important in understanding their role in this disease. |
| Keywords: | MLH1 Polymorphism Prostate Cancer |
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