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A1/A2 polymorphism of GpIIIa gene and a risk of aneurysmal subarachnoid haemorrhage |
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| Authors: | Mateusz G. Adamski Anna Borratynska Dorota Wloch-Kopec Pawel Wolkow Andrzej Urbanik Andrzej Szczudlik |
| Affiliation: | a Department of Neurology, Jagiellonian University Medical College, 3 Botaniczna St., 31-503 Krakow, Poland b Department of Neurosurgery and Neurotraumatology, Jagiellonian University Medical College, Krakow, Poland c Department of Pharmacology, Jagiellonian University Medical College, Krakow, Poland d Department of Radiology, Jagiellonian University Medical College, Krakow, Poland |
| Abstract: | Platelet glycoproteins are involved in pathophysiology of cerebrovascular diseases. The aim of this study was to investigate the association between the GpIIIa gene A1/A2 polymorphism and a risk of aneurysmal subarachnoid haemorrhage (SAH) in a Polish population. In a case-control study we genotyped 288 Caucasian patients with aneurysmal SAH and 457 age-, gender- and race-matched controls. The GpIIIa A1/A2 polymorphism was genotyped with RFLP technique. No difference was found in the distribution of the polymorphism between the cases and controls (cases: A1A1—201 (69.8%), A1A2—83 (28.8%) and A2A2—4 (1.4%) vs. controls: A1A1—323 (70.7%); A1A2—128 (28.0%); A2A2—6 (1.3%), P > 0.05. In a multivariate analysis female gender (OR = 1.950; 95%CI: 1.308-2.907), hypertension (OR = 4.774; 95%CI: 3.048-7.478) and smoking (OR = 2.034; 95%CI: 1.366-3.030), but not GpIIIa A1/A2 polymorphism, were independent risk factors for aneurysmal SAH. The GpIIIa A1/A2 polymorphism is not a risk factor of aneurysmal SAH in a Polish population. |
| Keywords: | GpIIIa GpIIIa A1/A2 polymorphism Aneurysmal SAH |
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