Abnormalities in aggression and anxiety in transgenic mice overexpressing activin E |
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Authors: | Kazunari Sekiyama Yuuki Ushiro Takefumi Kikusui Yoshihisa Hasegawa |
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Institution: | a Laboratory of Experimental Animal Science, Faculty of Veterinary Medicine, Kitasato University, School of Veterinary Medicine, 35-1 Higashi 23 Bancho, Towada-shi, Aomori 034-8628, Japan b Companion Animal Research, Azabu University, 1-17-1 Fuchinobe, Sagamihara-shi, Kanagawa 229-8501, Japan c National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan |
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Abstract: | To study the function of activin E, a TGF-β superfamily member, in the regulation of affective behavior, we investigated the behavior of transgenic mice overexpressing activin E (TgActβE mice). Male TgActβE mice showed aggressive behavior in resident-intruder tests. In elevated plus-maze tests, the percentage of open arm entries was significantly increased in female TgActβE mice compared with that in wild-type mice. Furthermore, female TgActβE mice stayed in the central area for a significantly longer time than wild-type mice in open field tests. These results indicated that TgActβE mice had less anxiety-like behavior. The number of restraint-stress-evoked c-Fos-positive cells in the hypothalamic paraventricular nucleus in TgActβE mice was significantly decreased compared with that in wild-type mice. This suggests that synthesis of corticotrophin-releasing hormone induced by stress was decreased in TgActβE mice. Taking these results together, activin E may act as a regulator of the hypothalamic-pituitary-adrenal axis. |
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Keywords: | Activin E Aggression Anxiety Transgenic mouse |
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