CpG island methylation pattern in different human tissues and its correlation with gene expression |
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| Authors: | Shicai Fan Xuegong Zhang |
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| Affiliation: | a School of Automation Engineering, University of Electronic Science and Technology of China, Chengdu 610054, China
b MOE Key Laboratory of Bioinformatics and Bioinformatics Division, TNLIST/Department of Automation, Tsinghua University, Beijing 100084, China |
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| Abstract: | The study on DNA methylation pattern in different human tissues attracts increasing interest nowadays, but a systematic analysis of CpG island methylation pattern between both somatic tissues and gametocyte is still lacking. In this work, we analyzed the CpG island methylation data of sperm and other 11 somatic tissues from Human Epigenome Project, and found that the CpG island methylation profiles are highly correlated between somatic tissues, while the methylation profile in sperm is quite distinct. Furthermore, we observed that in the six tissues investigated, there is no obvious correlation between the methylation level of promoter CpG islands and corresponding gene expression across different tissues. |
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| Keywords: | DNA methylation CpG island Methylation pattern Gene expression |
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