| 法尼酯衍生物X受体（FXR）在糖尿病肾病中的研究进展 |
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| 引用本文： | 熊浩君,赵凯,陈姗,何凤田,陈丙波.法尼酯衍生物X受体（FXR）在糖尿病肾病中的研究进展[J].中国实验动物学杂志,2012(7):64-68. |
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| 作者姓名： | 熊浩君 赵凯 陈姗 何凤田 陈丙波 |
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| 作者单位： | 第三军医大学实验动物中心,第三军医大学生物化学与分子生物学教研室,重庆400038 |
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| 基金项目： | 重庆市科技攻关重点项目（CSTC,2011AB1045）;重庆市科技攻关重点项目（CSTC,2011GG10014）. |
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| 摘 要： | 糖尿病肾病（DN）是糖尿病常见的慢性微血管并发症,最初是由高血糖引起的肾脏适应性高滤过率,进而导致肾脏细胞的代偿性增生、炎症以及纤维化。法尼酯X受体（FXR）被证明对糖尿病肾病有负性调节的作用,FXR可以通过不同的方面（血糖、血脂、炎症以及纤维化）对糖尿病肾病进行调控,从而有效的控制糖尿病肾病的发生和发展。本文将对FXR以及FXR调控糖尿病肾病的不同方面予以综述。
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| 关 键 词： | 糖尿病肾病 FXR 血糖 肾纤维化 炎症 |
The Role of Farnesoid X Receptor in Diabetic Nephropathy |
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| XIONG Hao-jun,ZHAO Kai,CHEN Shah,HE Feng-tian,CHEN Bing-bo.The Role of Farnesoid X Receptor in Diabetic Nephropathy[J].Chinese Journal of Laboratory Animal Science,2012(7):64-68. |
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| Authors: | XIONG Hao-jun ZHAO Kai CHEN Shah HE Feng-tian CHEN Bing-bo |
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| Institution: | (Laboratory animal center of Third Military Medicine University, Biochemistry and molecular biology laboratory of Third Military Medicine University, Chongqing 400037, China) |
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| Abstract: | Diabetic Nephropathy is well known as complication of microvessel disease caused by diabetes. High glucose leads to compensable high filtration rate of kidney, and then contribute to kidney cell groth, inflammation and fibrosis. Farnesoid X Receptor has been proved to ameliorate diabetic nephropathy. FXR can improve diabetic nephropathy through different aspects such as glucose, lipid, inflammation and fibrosis. How FXR improve diabetic nephropathy will be discussed in this review. |
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| Keywords: | Diabetic Nephropathy FXR Glucose Lipid Inflammation |
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