| Rab23研究进展 |
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| 引用本文： | 唐利,刘博强,李承新.Rab23研究进展[J].生物磁学,2012(26):5192-5194. |
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| 作者姓名： | 唐利 刘博强 李承新 |
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| 作者单位： | 第四军医大学西京医院全军皮肤病研究所,陕西西安710032 |
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| 摘 要： | Rab23为小GTP结合蛋白，是Ras超家族Rab家族成员，其突变可引起小鼠开脑综合征（openbrain syndrome），因此又称为opb基因。它是Sonic hedgehog信号通路的负调控因子，在不同肿瘤中发挥不同作用，并参与机体组织器官的发育和分化。它可能通过转运细胞内蛋白发挥相关作用。
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| 关 键 词： | Rab23 Rab Hedgehog信号通路 Carpenter综合征 |
Advances of Rab23 |
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| TANG Li,LIU Bo-qiang,LI Cheng-xin.Advances of Rab23[J].Biomagnetism,2012(26):5192-5194. |
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| Authors: | TANG Li LIU Bo-qiang LI Cheng-xin |
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| Institution: | (Department of dermatology, Xijing Hospital, Forth Military Medical University, Xi＇an 710032, China) |
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| Abstract: | Rab23, which is also called opb gene, belongs to the small GTPase superfamily, Rab family. The mutation of Rab23 can induce open brain syndrome of mice. It is an essential negative regulator of the sonic hedgehog signaling pathway. Rab 23 have recently been implicated in carcinogenesis, development and differentiation of tissue. The mechanism how Rab23 works may due to the trafficking of intracellular proteins. |
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| Keywords: | Rab23 Rab Hedgehog signaling pathway Carpenter syndrome |
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