亚高原与高原地区绵羊多脏器功能障碍综合症血清生化指标的比较

目的本文旨在通过不同的海拔高原地区的多脏器功能障碍综合征（MODS）绵羊模型的生化指标来探讨MODS的高原性发病特点。方法将12只绵羊随机分为两组,每组6只,分别在高原地区夏河桑科草原（平均海拔在3100 m）和亚高原地区兰州市（平均海拔在1520 m）,动物全麻后,以6μg/kg内毒素（LPS）于30 min内静脉泵入建立MODS模型。观察各组的体征表现,测定不同时点各组血清生化指标的改变。结果高原地区的MODS模型绵羊死亡率以及不同时段血清的CK、CK-MB、AST、ALT、CRE生化指标明显高出亚高原地区,只有ALP指标亚高原地区与高原地区的变化基本相近。结论 MODS在伴随着海拔升高的高原地区危害程度更大。

Comparison Biochemical Indexes in Serum in Sub-highland between Highland in Multiple Organ Dysfunction Syndrome Induced in Sheep

Objective To investigate the morbility of MODS in different altitude and observe the change of blood biochemistry by the animal model of multiple orgen dysfunction syndrome（MODS） induced by lipopolysaccharide（LPS） in sheep.Methods 12 sheep were randomly separated into 2 groups,6 sheep each group： the highland region of Sangke prairie（average altitude 3100 m）,sub highland region of Lanzhou group（average altitude 1520 m）.After anaesthetizing,the MODS model was established by infusing 6 μg / kg LPS in 30 minutes intravenously in sheep.Then the physical sign appearance was observed and the indexes of blood biochemistry were determined in each group at different times.Results The sheep in Sangke group,the death rate was markedly raised.The CK、CK-MB、AST、ALT、CRE biochemical indexes was markedly higher compared with Lanzhou group,except ALP that was little change.Conclusion MODS has the more damage in multiple organ follow on the raising altitude at highland.