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Transferrin microheterogeneity as a probe in normal and disease states |
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| Authors: | G. De Jong R. Feelders W. L. Van Noort H. G. Van Eijk |
| Affiliation: | (1) Department of Chemical Pathology, Medical Faculty, Erasmus University, 3000 DR Rotterdam, The Netherlands;(2) Department of Internal Medicine II, Academic Hospital Dijkzigt Rotterdam, Dr Molewaterplein 40, 3000 DR Rotterdam, The Netherlands |
| Abstract: | Isoelectric focusing of iron saturated serum has been established as a convenient method for showing transferrin glycan microheterogeneity. In a clinical setting, the method is used in the detection of cerebrospinal fluid leakage, the screening for surreptitious alcohol abuse and in the diagnosis of the carbohydrate deficient glycoprotein syndrome. In normal physiological states it can also be used as a tool to probe for changes in N-glycosylation. |
| Keywords: | transferrin microheterogeneity isoelectric focusing iron saturated serum cerebrospinal fluid leakage alcohol abuse carbohydrate deficient glycoprotein syndrome N-glycosylation |
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