LAS inhibition of diffusion and uptake of tritiated uridine during teleost embryogenesis |
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Authors: | Harold W Manner Carol Muehleman |
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Institution: | (1) Loyola University of Chicago, Chicago, Illinois 60626, USA |
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Abstract: | Synopsis Fathead minnow embryos (Pimephales promelas Rafinesque) of 5 different developmental ages (5, 33, 48, 72 and 96 hrs after fertilization) were used as controls and exposed for 2 hrs to a solution of 0.25 Ci ml–1 of3H-Uridine. Another set of embryos (5, 33, 48, 72 and 96 hrs after fertilization) were subjected to the same treatment except that during the one hour immediately preceding the3H-Uridine incubation, the control embryos were placed in water while the experimental embryos were placed in water containing 15 ppm 11.2 LAS. In both cases, radiation counts minute–1 embryo–1 and per milligram of embryo increased over the 4 day developmental period. The embryos with LAS treatment displayed lower radiation counts at all ages as compared to controls, indicating an inhibition of diffusion and uptake of3H-Uridine and/or RNA synthesis. The possible mechanism of LAS is discussed. |
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Keywords: | Chorion permeability Linear alkyl benzene sulfonate Pimephales promelas Pollutants Teleost Embryogenesis Toxicity |
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