Marsupial-specific microRNAs evolved from marsupial-specific transposable elements |
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| Authors: | Eric J. Devor Andrew S. Peek William Lanier Paul B. Samollow |
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| Affiliation: | 1. Molecular Genetics and Bioinformatics, Integrated DNA Technologies, Coralville, IA 52241, USA;2. Interdisciplinary Program in Genetics, University of Iowa, Iowa City, IA 52242, USA;3. Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, TX 77843-4461, USA |
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| Abstract: | Using a direct miRNA cloning strategy we previously identified fourteen marsupial- or species-specific microRNAs in the marsupial species Monodelphis domestica. In the present study we examined each of the pre-miRNAs and their flanking sequences and demonstrate that half of these miRNAs evolved from marsupial-specific transposable elements. These findings reinforce the view that transposable elements are a previously unappreciated source of new, lineage-specific microRNAs. |
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| Keywords: | pre-miRNA, microRNA precursor miRNA, microRNA TE, transposable element kb, kilobase bp, base pair Mdo, Monodelphis domestica miR, microRNA locus ΔG, folding free energy kcal, kilocalories |
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