Complement inhibiting properties of dragon's blood from Croton draco |
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| Authors: | Tsacheva Ivanka Rostan Joerg Iossifova Tania Vogler Bernhard Odjakova Mariela Navas Hernan Kostova Ivanka Kojouharova Michaela Kraus Wolfgang |
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| Institution: | Department of Biochemistry, Faculty of Biology, Sofia University, 1164 Sofia, Bulgaria. |
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| Abstract: | The latex of Croton draco, its extracts and several latex components have been investigated for their influence on both classical (CP) and alternative (AP) activation pathways of the complement system using a hemolytic assay. The best inhibition was found for the classical pathway. The latex, ethyl acetate and ethyl ether extracts exhibited extremely high inhibition on the CP (94, 90 and 77%, respectively) at a concentration of 1 mg/ml. The flavonoid myricitrin, the alkaloid taspine and the cyclopeptides P1 and P2 showed high inhibition on CP (83, 91, 78 and 63%, respectively) at a concentration of 0.9 mM. |
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