Mitochondrial calcium in the life and death of exocrine secretory cells |
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Authors: | Voronina Svetlana Tepikin Alexei |
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Institution: | Department of Cellular and Molecular Physiology, The Physiological Laboratory, Institute of Translational Medicine, The University of Liverpool, Crown Street, Liverpool L69 3BX, UK. |
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Abstract: | The remarkable recent discoveries of the proteins mediating mitochondrial Ca(2+) transport (reviewed in this issue) provide an exciting opportunity to utilise this new knowledge to improve our fundamental understanding of relationships between Ca(2+) signalling and bioenergetics and, importantly, to improve the understanding of diseases in which Ca(2+) toxicity and mitochondrial malfunction play a crucial role. Ca(2+) is an important activator of exocrine secretion, a regulator of the bioenergetics of exocrine cells and a contributor to exocrine cell damage. Exocrine secretory cells, exocrine tissues and diseases affecting exocrine glands (like Sj?gren's syndrome and acute pancreatitis) will, therefore, provide worthy research areas for the application of this new knowledge of the Ca(2+) transport mechanisms in mitochondria. |
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