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In vitro SAR of (5-(2H)-isoxazolonyl) ureas, potent inhibitors of hormone-sensitive lipase |
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| Authors: | Lowe Derek B Magnuson Steven Qi Ning Campbell Ann-Marie Cook James Hong Zhenqiu Wang Ming Rodriguez Mareli Achebe Furahi Kluender Harold Wong Wai C Bullock William H Salhanick Arthur I Witman-Jones Terri Bowling Mary E Keiper Christine Clairmont Kevin B |
| Affiliation: | Department of Chemistry Research, Bayer Research Center, 400 Morgan Lane, West Haven, CT 06516, USA. derek.lowe.b@bayer.com |
| Abstract: | A series of (5-(2H)-isoxazolonyl) ureas were developed as nanomolar inhibitors of hormone-sensitive lipase, an enzyme of potential importance in the treatment of diabetes. |
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