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The Murine CAR Homolog Is a Receptor for Coxsackie B Viruses and Adenoviruses |
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| Authors: | Jeffrey M. Bergelson Anita Krithivas Leo Celi Gustavo Droguett Marshall S. Horwitz Thomas Wickham Richard L. Crowell Robert W. Finberg |
| Affiliation: | Division of Infectious Diseases, Dana-Farber Cancer Institute, Boston, Massachusetts 021151.; Departments of Microbiology-Immunology2. and Pediatrics,3. Albert Einstein College of Medicine, Bronx, New York 10461; GenVec, Inc., Rockville, Maryland 208524.; and Department of Microbiology and Immunology, Medical College of Pennsylvania and Hahnemann University, Philadelphia, Pennsylvania 191025. |
| Abstract: | Complementary DNA clones encoding the murine homolog (mCAR) of the human coxsackievirus and adenovirus receptor (CAR) were isolated. Nonpermissive CHO cells transfected with mCAR cDNA became susceptible to infection by coxsackieviruses B3 and B4 and showed increased susceptibility to adenovirus-mediated gene transfer. These results indicate that the same receptor is responsible for virus interactions with both murine and human cells. Analysis of receptor expression in human and murine tissues should be useful in defining factors governing virus tropism in vivo. |
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