A new candidate for the regulation of erythropoiesis. Insulin-like growth factor I |
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Authors: | A Kurtz W Jelkmann C Bauer |
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Affiliation: | 1. Institute de Biochimie, Université de Lausanne, ch. des Boveresses, 1066 Epalinges, Switzerland;2. Istituto Scientifico per lo Studio e la Cura dei Tumori, Viale Benedetto XV, 10, 16132 Genova, Italy |
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Abstract: | The effect of pure human insulin-like growth factor I (IGF I) on the colony formation of late stage erythroid precursor cells (CFU-e) from fetal mouse liver and adult bone marrow was studied in a serum-free culture system. We found that IGF I in physiological concentrations stimulated erythroid colony formation. The combined effect of IGF I and erythropoietin was smaller than the sum of their single effects. The number of colonies induced by IGF I was linearly dependent on the number of plated cells. Our results indicate that IGF I is the first clearly defined mitogen that stimulates the late stages of erythroid differentiation independently of erythropoietin. |
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Keywords: | Fibronectin Human milk Protein blotting Fibronectin fragments |
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