Plasma membrane coenzyme Q10 and growth control |
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Authors: | C Gómez-Díaz M P Barroso P Navas |
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Institution: | (1) Departmento de Biología Celular, Facultad de Ciencias, Universidad de Córdoba, Córdoba;(2) Laboratorio Andaluz de Biología, Universidad Pablo de Olavide, Carretera de Utrera km. 1, E-41013 Sevilla, Spain |
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Abstract: | Summary Coenzyme Q is distributed among cellular membranes and it has a significant concentration at the plasma membrane. The plasma
membrane contains a trans-membrane electron transport system, which is centered on coenzyme Q. This molecule is maintained
reduced by NAD(P)H-dependent enzymes and can reduce other antioxidants such as tocopheroxyl quinone and ascorbate free radical.
Its antioxidant property and its ability to maintain in the reduced state the other antioxidants offers a system to protect
membrane components against oxidations and prevents oxidative-stress-dependent cellular damage. Growth factor withdrawal induces
cell growth arrest and apoptosis through an oxidative-stress-induced pathway. Coenzyme Q can stimulate growth of different
cell lines under serum deficiency, mainly by preventing apoptosis. The protection caused by coenzyme Q is independent of the
Bcl-2 protein. Plasma membrane coenzyme Q appears to be essential in the regulation of the redox equilibrium of the cell and
redox-dependent pathways. |
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Keywords: | Plasma membrane Coenzyme Q Antioxidant Cell growth Apoptosis |
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