The effect of isoprenaline on the phospholipid content of the compact and spongious musculature of the carp ventricular myocardium |
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| Authors: | J Drnková O Nováková V Pelouch B Ostádal V Kubista |
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| Institution: | Department of Animal Physiology and Developmental Biology, Faculty of Natural Sciences, Charles University, Vinicná, Czechoslovakia. |
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| Abstract: | 1. After a single injection of 40 mg kg-1 of isoprenaline to the carp, lysophospholipids appear in the tissue of the heart ventricle, ethanolamine plasmalogens increase and choline plasmalogens decrease; phosphatidylinositol is lowered in the spongious layer only. 2. Daily administration of 5 mg kg-1 of the drug leads, after 5 doses, to a dramatic decrease of the diphosphatidylglycerol content; during the subsequent 5 and 10 doses a return to normal values occurs. Shifts in plasmalogens are similar to those found after a single high dose. Some other phospholipids change significantly. 3. All changes reveal that the spongious musculature is more sensitive to the drug than the compact one. |
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