Fluorometric analysis of polyamines, histamine, and 1-methylhistamine. |
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| Authors: | F Perini J B Sadow C V Hixson |
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| Institution: | Biological Markers Laboratory, NCI Frederick Cancer Research Center, P.O. Box B, Frederick, Maryland 21701 USA |
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| Abstract: | This paper describes an automated cation-exchange chromatographic method for the simultaneous analysis of di- and polyamines, histamine, and its metabolite 1-methylhistamine. Recommendations for the selection of an effective system are made after evaluating sodium- and potassium-containing buffers, pH, temperature, column packings, and detection methods. The method can be used to analyze di- and polyamines in biological fluids, such as urine and tissue extracts, and may be useful for monitoring the effectiveness of cancer chemotherapy. |
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| Keywords: | Address reprint requests to Dr Fulvio Perini Frederick Cancer Research Center P O Box B Frederick Md 21701 |
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