Sequence Analysis of a 25-kb Segment in the 17{degrees}-19{degrees} Region of the Bacillus subtilis Chromosome Containing ada Locus |
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| Authors: | Liu Hongtu; Haga Koki; Kasahara Yasuhiro; Ogasawara Naotake; Takahashi Hideo; Yoshikawa Hirofumi |
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| Institution: | 1Institute of Molecular and Cellular Biosciences, The University of Tokyo Bunkyo-ku, Tokyo 113, Japan
2Graduate School of Biological Sciences, Nara Institute of Science and Technology 8916-5, Takayama, Ikoma, Nara 630-01, Japan |
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| Abstract: | As a part of the Bacillus subtilis genome sequencing project,we have determined a 25-kb sequence covering the 17°–19°region. This region contains 26 complete open reading frames(ORFs) including the alkA and adaA/B operon, which encode genesfor adaptive response to DNA alkylation. A homology search forthe newly identified 21 ORFs revealed that 4 of them exhibita significant similarity to known proteins, e.g., methicillin-resistantStaphylococcus aureus (MRSA) protein homolog, proteins involvedin chloramphenicol resistance, glucosamine synthase and an ABCtransporter protein. The remaining 17 ORFs did not show anysignificant sequence similarities to known gene products inthe database. |
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| Keywords: | Bacillus subtilis genome sequencing 17° – 19° region ada locus |
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