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Sequence Analysis of a 25-kb Segment in the 17{degrees}-19{degrees} Region of the Bacillus subtilis Chromosome Containing ada Locus
Authors:Liu, Hongtu   Haga, Koki   Kasahara, Yasuhiro   Ogasawara, Naotake   Takahashi, Hideo   Yoshikawa, Hirofumi
Affiliation:1Institute of Molecular and Cellular Biosciences, The University of Tokyo Bunkyo-ku, Tokyo 113, Japan
2Graduate School of Biological Sciences, Nara Institute of Science and Technology 8916-5, Takayama, Ikoma, Nara 630-01, Japan
Abstract:As a part of the Bacillus subtilis genome sequencing project,we have determined a 25-kb sequence covering the 17°–19°region. This region contains 26 complete open reading frames(ORFs) including the alkA and adaA/B operon, which encode genesfor adaptive response to DNA alkylation. A homology search forthe newly identified 21 ORFs revealed that 4 of them exhibita significant similarity to known proteins, e.g., methicillin-resistantStaphylococcus aureus (MRSA) protein homolog, proteins involvedin chloramphenicol resistance, glucosamine synthase and an ABCtransporter protein. The remaining 17 ORFs did not show anysignificant sequence similarities to known gene products inthe database.
Keywords:Bacillus subtilis   genome sequencing   17°    19°   region   ada locus
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