Bacterial protein toxins targeting rho GTPases |
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Authors: | Lerm M Schmidt G Aktories K |
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Affiliation: | Center for Oral Biology and Department of Microbiology and Immunology, University of Rochester Medical Center, Box 611, 601 Elmwood Ave., Rochester, NY 14642, USA. robert_burne@urmc.rochester.edu |
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Abstract: | Several bacterial protein toxins target eukaryotic cells by modulating the functions of Rho GTPases that are involved in various signal processes and in the regulation of the actin cytoskeleton. The toxins inhibit Rho functions by ADP-ribosylation or glucosylation and activate them by deamidation and transglutamination. New findings indicate that the GTPases are also targeted by various 'injected' toxins which are introduced into the eukaryotic cells by the type-III secretion system. The injected toxins do not covalently modify Rho GTPases, but manipulate their regulatory GTPase cycle by acting as GTPase-activating proteins or guanine nucleotide exchange factors. |
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Keywords: | Rho GTPase Toxin Glucosylation Type-III secretion ADP-ribosylation Clostridium difficile toxin Deamidation Transglutamination Cytotoxic necrotising factor |
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