Quantitative analysis of cell nucleus organisation |
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| Authors: | Shiels Carol Adams Niall M Islam Suhail A Stephens David A Freemont Paul S |
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| Institution: | Division of Molecular Biosciences, Faculty of Natural Sciences, Imperial College London, London, United Kingdom |
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| Abstract: | There are almost 1,300 entries for higher eukaryotes in the Nuclear Protein Database. The proteins' subcellular distribution patterns within interphase nuclei can be complex, ranging from diffuse to punctate or microspeckled, yet they all work together in a coordinated and controlled manner within the three-dimensional confines of the nuclear volume. In this review we describe recent advances in the use of quantitative methods to understand nuclear spatial organisation and discuss some of the practical applications resulting from this work. |
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