Consecutive zinc balance trials in growing rats |
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Authors: | H G Petering E Giroux H Choudhury E E Menden |
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Institution: | (1) Institute of Environmental Health, Kettering Laboratory, University of Cincinnati Medical Center, 45267 Cincinatti, Ohio;(2) Merrell Research Center, Merrell Dow Pharmaceuticals, 45215 Cincinnatti, Ohio |
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Abstract: | Rats were fed a purified egg white-based diet containing 5 ppm Cu and 2, 14, or 57 ppm Zn. Zinc and copper balances were determined
for eight consecutive weekly trial periods. The zinc-deficient group almost ceased to gain weight and was in slightly negative
zinc balance. Groups of rats fed 14 and 57 ppm Zn gained weight at equal rates. These groups were in strongly positive zinc
balance for four weeks; thereafter, they fed 57 ppm Zn retained about two times as much zinc as did the group fed the diet
containing 14 ppm Zn. All groups were in null or slightly negative copper balance throughout the trial. These results suggest
that zinc accumulation may be homeostatically controlled to a level in excess of that needed for maximum growth. |
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Keywords: | Zinc balance homeostasis of zinc copper balance optimal nutriture growth rate effect of Zn effect of zinc on copper metabolism |
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