A simple and efficient approach to the synthesis of 4H-furo[3,4-b]pyrans via a three-component reaction of isocyanides |
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| Authors: | Shaabani Ahmad Soleimani Ebrahim Sarvary Afshin Rezayan Ali Hossein |
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| Institution: | aDepartment of Chemistry, Shahid Beheshti University, PO Box 19396-4716, Tehran 19839-4716, Iran |
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| Abstract: | A three-component reaction of an isocyanide, a dialkyl acetylenedicarboxylate, and tetronic acid in dichloromethane at room temperature afforded 4H-furo3,4-b]pyran derivatives. These compounds are closely related with ring systems, TAN-2483B, TAN-2483A, and FD-211 which have a broad spectrum of biological activity. |
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| Keywords: | Multi-component reaction Isocyanide Tetronic acid 4H-furo[3 4-b]pyran |
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