New data on clonal anomalies of chromosome 14 in ataxia telangiectasia: tct (14;14) and inv(14) |
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Authors: | Aurias A. Croquette M. F. Nuyts J. P. Griscelli C. Dutrillaux B. |
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Affiliation: | (1) Structure et Mutagenèse Chromosomiques, CNRS UA N.620, Institut Curie, Section de Biologie, 26 Rue d'Ulm, F-75231 Paris, Cédex 05, France;(2) Laboratoire de Biologie médicale, 194 Rue Nationale, Lille, France;(3) Service Neurologie Infantile, Hôpital Calmette CHR, Lille, France;(4) Unité d'Immuno-Hématologie, Hôpital des Enfants Malades, Paris, France |
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Abstract: | Summary From a series of 53 patients with ataxia telangiectasia, two large clones with a t tan or tct(14;14) and two with an inv(14) were observed among phytohaemagglutinin (PHA)-stimulated lymphocytes. Smaller clones with the same inv(14) were observed in two other cases. Similar breakpoints may exist, both for t(14;14) and inv(14): q11.1/q11.2 and q32, and it is postulated that the rearrangements are related to a recombination of the -chain of the T-cell receptor and IgH clusters of genes. |
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