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Generation of Tumor Antigen-Specific iPSC-Derived Thymic Emigrants Using a 3D Thymic Culture System
Authors:Raul Vizcardo  Nicholas D. Klemen  S.M. Rafiqul Islam  Devikala Gurusamy  Naritaka Tamaoki  Daisuke Yamada  Haruhiko Koseki  Benjamin L. Kidder  Zhiya Yu  Li Jia  Amanda N. Henning  Meghan L. Good  Marta Bosch-Marce  Takuya Maeda  Chengyu Liu  Zied Abdullaev  Svetlana Pack  Douglas C. Palmer  Nicholas P. Restifo
Affiliation:1. Surgery Branch, National Cancer Institute, NIH, Bethesda, MD 20892, USA;2. Center for Cell-Based Therapy, National Cancer Institute, NIH, Bethesda, MD 20892, USA;3. Laboratory of Developmental Genetics, RIKEN Center for Integrative Medical Science, Yokohama, Kanagawa 230-0045, Japan;4. Department of Oncology and Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA;5. Transgenic Core, Division of Intramural Research, National Heart, Lung and Blood Institute, NIH, Bethesda, MD 20892, USA;6. Experimental Pathology Laboratory, National Cancer Institute, NIH, Bethesda, MD 20892, USA;7. Department of Transfusion Medicine Department, Clinical Center, NIH, Bethesda, MD 20892, USA;8. Department of Surgical Oncology, Roswell Park Cancer Center, Buffalo, NY 14263, USA;9. Center for Immunotherapy, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA;10. Experimental Transplantation and Immunology Branch, NIH Clinical Center, NIH, Bethesda, MD 20892, USA;11. Experimental Immunology Branch, National Cancer Institute, NIH, Bethesda, MD 20892, USA
Abstract:
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  • Keywords:thymopoiesis  T cell differentiation  iPSC differentiation  adoptive cell transfer  naïve T cell  recent rhymic emigrants  fetal thymus organ culture  immunotherapy  3D culture  tumor antigen specific T cell
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